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Multisensory memory consolidation in hippocampal-cortical circuits in mice and human

AdaBD made easy

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How does the brain turn multisensory experiences—like sights, sounds, and touch—into long-term memories?

This project studies how different brain areas work together to encode and consolidate sensory experiences in both mice and humans. We aim to uncover how multisensory memory formation normally occurs and why it can be disrupted. 

Research project

Our memories of daily life often involve multiple senses, such as sights, sounds, and spatial
information. This project investigates how the brain integrate these multisensory experiences into long-term memories. By using similar multisensory tasks in mice and humans, we will study how the cortex and hippocampus encode and consolidate multisensory experience. Understanding these fundamental principles will enable us to further explore how these processes are disrupted in autism spectrum disorder (ASD). By bridging findings across brain areas and species, this project aims at uncovering key memory mechanisms and improving our understanding of multisensory integration in both healthy and ASD brains

Research Groups

Principal Investigators: Shuting Han, Reto Huber, Xiaomin Zhang

Publications

Han S, Helmchen F (2025)
Coordinated multi-level adaptations across neocortical areas during task learning
Nature Communications ,7719

Underlined: Current and previous AdaBD researchers