The mesoSPIM microscopy platform offers to basic and clinical scientists three custom-built light-sheet microscopes that allow 3D imaging of chemically cleared samples that are too large for traditional microscopes, such as entire mouse brains or post-mortem human tissues. Images are taken through a laser scanning technique, without cutting the samples into slices, a process called light-sheet imaging.
Our platform offers a comprehensive range of services, including user training, consulting, customization of software and hardware. Further, we carry out our own research and development in light-sheet microscopy, further developing our microscopes as an open-source project, including video tutorialsand user meetings. In 2023, we reached a milestone by completing a new generation of mesoSPIM microscopes, the Benchtop microscope, which is more compact, easier to build, portable and affordable. Moreover, it has improved optics, higher resolution, and a larger field of view.
The mesoSPIM technology allows unprecedented analysis of brain circuits architecture, from embryo to adulthood. This facilitates research of several groups within our URPP and beyond, who investigate brain circuits during development in health and disease.
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